Assist Items are special items that can aid the player in completing the level in ways that normal power-ups can't. They can only be purchased at a Shop, but you can have up to four of them at one time. You can only have one copy of each item at a time. All characters share Assist Items with no character-specific ones.
- Reserve Tank: This item will allow you to take an extra hit when it would normally be fatal. It doesn't protect from instant-kill objects, however.
- Beat: Mega Man's bird will swoop down and pull you out of a pit if you fall in, as well as glide you for a short distance to reach safety.
- Protective Crystal: A barrier from Kid Icarus, two gems rotate around your character to protect against weak projectiles and enemies. It says with the character until death.